November 6, 2009 Middle-aged women with high levels of a specific amino acid in their blood are twice as likely to suffer from Alzheimer's many years later, reveals a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden. This discovery this could lead to a new and simple way of determining who is at risk long before there are any signs of the illness.
"Alzheimer's disease was more than twice as common among the women with the highest levels of homocysteine than among those with the lowest, and the risk for any kind of dementia was 70 per cent higher," says doctor Dimitri Zylberstein, author of the thesis.
Is homocysteine an iron-dependent cardiovascular risk factor? J L Sullivan1
1Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA
Correspondence: Jerome L. Sullivan, 4475 Old Bear Run, Winter Park, FL 32792, USA. E-mail: jlsulli...@pol.net
Top of pageAbstract Recent studies of endothelial function suggest that adverse vascular effects of homocysteine are iron-dependent. Iron sucrose worsens and iron chelation eliminates homocysteine-associated decreases in flow- mediated dialation. There may be no vasculopathic effect of homocysteine without available reactive iron. Iron-dependent amplification of the vascular effects of homocysteine may be one of several mechanisms by which stored iron increases cardiac risk.
Kidney International (2006) 69, 642–644. doi:10.1038/sj.ki.5000229
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Iron-dependent formation of homocysteine from methionine and other thioethers. Baggott JE, Tamura T. 1Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Objective: We tested whether homocysteine is formed from methionine andother thioethers in vitro and in vivo, because methionine can be chemically demethylated to homocysteine. Design: In in vitro studies, chemical conversions of thioethers (methionine, S-adenosylhomocysteineand cystathionine) into homocysteine were measured under various aerobic conditions. In humans, oral methionine (0.17 mmol/kg bodyweight) loading tests with and without an oral iron dose (ferrous sulfate, 13 mumol/kg) were performed. Setting: A university setting in Birmingham, AL, USA. Subjects: A total of five healthy adult subjects volunteered. Results: The in vitro incubation of methionine, S- adenosylhomocysteine or cystathionine with chelated iron resulted in the formation of homocysteine. These conversions were iron- and pH-dependent (pH optima between 5.0 and 6.0) and it was also chelator-dependent. In humans, oral methionine loading tests resulted in a 45% increase in the area-under-the-curve for plasma total homocysteine concentrations, when iron was given together with methionine. Conclusion: Our data suggest that iron-dependent chemical formation of homocysteine can occur in vivo, and contribute to the plasma total homocysteine pool, since this formation can occur ceaselessly. We hypothesize that plasma total homocysteine concentrations reflect, in part, non-protein-bound iron in the body.
European Journal of Clinical Nutrition advance online publication, 14 February 2007; doi:10.1038/sj.ejcn.1602665.
On Nov 8, 11:12 am, ironjustice <ironjust...@rock.com> wrote: In humans, oral methionine loading tests resulted in a 45% increase in the area-under-the-curve for plasma total homocysteine concentrations, when iron was given together with methionine. <<
"When iron was given together with methionine"
THAT means when you have a sandwitch .. the iron they have ADDED to the flour CAUSES the methionine which is found in EVERY friggin food you eat .. to KILL you ..
> November 6, 2009 Middle-aged women with high levels of a specific > amino acid in their blood are twice as likely to suffer from > Alzheimer's many years later, reveals a thesis from the Sahlgrenska > Academy at the University of Gothenburg, Sweden. This discovery this > could lead to a new and simple way of determining who is at risk long > before there are any signs of the illness.
> "Alzheimer's disease was more than twice as common among the women > with the highest levels of homocysteine than among those with the > lowest, and the risk for any kind of dementia was 70 per cent higher," > says doctor Dimitri Zylberstein, author of the thesis.
> Is homocysteine an iron-dependent cardiovascular risk factor? > J L Sullivan1
> 1Department of Pathology, Immunology and Laboratory Medicine, > University of Florida College of Medicine, Gainesville, FL, USA
> Correspondence: Jerome L. Sullivan, 4475 Old Bear Run, Winter Park, FL > 32792, USA. E-mail: jlsulli...@pol.net
> Top of pageAbstract > Recent studies of endothelial function suggest that adverse vascular > effects of homocysteine are iron-dependent. Iron sucrose worsens and > iron chelation eliminates homocysteine-associated decreases in flow- > mediated dialation. There may be no vasculopathic effect of > homocysteine without available reactive iron. Iron-dependent > amplification of the vascular effects of homocysteine may be one of > several mechanisms by which stored iron increases cardiac risk.
> Kidney International (2006) 69, 642–644. doi:10.1038/sj.ki.5000229
> --------------------
> Iron-dependent formation of homocysteine from methionine and other > thioethers. > Baggott JE, Tamura T. > 1Department of Nutrition Sciences, University of Alabama at > Birmingham, Birmingham, AL, USA.
> Objective: > We tested whether homocysteine is formed from methionine > andother thioethers in vitro and in vivo, because methionine can be > chemically demethylated to homocysteine. > Design: > In in vitro studies, chemical conversions of thioethers (methionine, > S-adenosylhomocysteineand cystathionine) into homocysteine were > measured under various aerobic conditions. > In humans, oral methionine (0.17 mmol/kg bodyweight) loading tests > with and without an oral iron dose (ferrous sulfate, 13 mumol/kg) > were > performed. > Setting: > A university setting in Birmingham, AL, USA. > Subjects: > A total of five healthy adult subjects volunteered. > Results: > The in vitro incubation of methionine, S- adenosylhomocysteine or > cystathionine with chelated iron resulted in the formation of > homocysteine. > These conversions were iron- and pH-dependent (pH optima > between 5.0 and 6.0) and it was also chelator-dependent. > In humans, oral methionine loading tests resulted in a 45% > increase in the area-under-the-curve for plasma total homocysteine > concentrations, when iron was given together with > methionine. > Conclusion: > Our data suggest that iron-dependent chemical formation of > homocysteine can occur in vivo, and contribute to the > plasma total homocysteine pool, since this formation can occur > ceaselessly. > We hypothesize that plasma total homocysteine > concentrations reflect, in part, non-protein-bound iron in the > body.
> European Journal of Clinical Nutrition advance online > publication, 14 February 2007; doi:10.1038/sj.ejcn.1602665.
THAT means when you have a sandwitch .. the iron they have ADDED to the flour CAUSES the methionine which is found in EVERY friggin food you eat .. to KILL you .."
And given that many foods contain iron anyway...?
"In theory .."
Oh dear, however can we stand it, finally a self constraint on all or nothing assertions.
Now take the eating meat and its iron is the cause of all disease assertion?
Not only theory, barely, but now completely trounced at that long since. Some theories like chickens with heads removed flutter about even though they do not yet realize it is all over.
