Message from discussion Folic acid receptor autoantibodies, vitamin D3 and milk consumption in autoimmune disease

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From: Michael B <baugh...@bellsouth.net>
Newsgroups: alt.support.sinusitis,alt.support.celiac,alt.support.crohns-colitis,sci.med.immunology,alt.med.fibromyalgia
Subject: Re: Folic acid receptor autoantibodies, vitamin D3 and milk 
	consumption in autoimmune disease
Date: Sat, 27 Jun 2009 19:26:48 -0700 (PDT)
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You're talking about your immune system working against you.

Curious thing, there. For a little over a year, I had been hearing
about low-dose Naltrexone, and quite frankly not believing it. My
clinical background caused me to be disdainful of a product with
essentially no clinical trials.

You all know how misleading anecdotal evidence can be. But a
woman that was pretty much written off as having only a few
months to live told me how the Naltrexone had given her a
second chance, and I attributed her surge to the sort of thing
very common before death. I didn't tell her she was deluding
herself, but I told a friend to be ready for a funeral.

Perhaps I was wrong. Low dose Naltrexone is being prescribed
by doctors all over the place, and a serious clinical trial showed
it helped a small group of women with fibromyalgia. I've seen
stories by people with Crohn's, Lupus, Rheumatoid Arthritis,
other autoimmune issues, several varieties of cancer.

But those are purely academic till you see someone getting
better from lung cancer.

I'm impressed. It's not a cure, it just helps the body's immune
processes be more appropriately directed, and that would be a
good thing to have on board for celiac, Crohn's, carcinoma,
or so many other conditions that depend on the immune
system to do its job by distinguishing its targets better.

But I'm not trying to sell something, don't know or care if you
do any research on it, don't care if you decide it is or isn't for
you or someone you know. But I do care that the protocol isn't
even being mentioned. Well, it is, but not much. I'm mentioning
it. Just for the purpose of inviting people to do some checking
on it. Your research, your choice, my invitation to look at a
"can't hurt, might help" thing.


On Jun 1, 3:54=A0am, Kofi <k...@anon.un> wrote:
> The FDA suspended manufacture of leucovorin (folinic acid) due to
> quality issues in early March and since then, I've been off it and doing
> rather poorly. =A0Supposedly production has resumed, but I've only been
> able to get one bottle. =A0It's lasted about a week. =A0Since folinic aci=
d
> has become key in a number of chemotherapies, its availability may
> remain limited for a while.
>
> Now that I'm back on it, it's like somebody turned on the vitamin D
> spigot again. =A0The results have been so dramatic it prompted me to dig
> deeper. =A0It turns out regulatory T-cells have folic acid receptors [PMI=
D
> 17613255] and certain autoimmune patients and low-functioning autistics
> [PMID 18461502] generate autoantibodies against folic acid receptors -
> quite possibly as the aftereffect of clearing out a viral infection or a
> cancer that trained B-cells to target the receptor.
>
> If these folic acid receptor antibodies are numerous enough, they can
> block entry of folic acid into the central nervous system. =A0The recepto=
r
> is necessary for folic acid to cross the blood-brain barrier. =A0A patien=
t
> with normal serum folic acid levels might actually be deficient in the
> CNS which would only show up in a tap - a procedure doctors rarely
> perform.
>
> It also turns out that low folic acid levels lead to higher vitamin D3
> catabolism [PMID 19450178] so if the CNS is deficient in folic acid,
> vitamin D3 isn't going to function properly - leading to a drop in redox
> capacity (e.g., low glutathione)/metals detoxification/neurogenesis,
> loss of antiviral functions/cathelicidin, increased cancer risk and
> probably autoimmune issues as well. =A0But it's going to be invisible to
> anybody checking strict serum levels. =A0It makes me wonder if certain
> vital infections don't deliberately stir up anti-folic acid receptor
> antibodies to block the antiviral effects of vitamin D3 within the
> nervous system itself.
>
> The upside, though, is that supplementing with folinic acid shots or a
> high dose oral folic acid seems to restore CNS levels [PMID 19260931]. =
=A0
> Folic acid per se may stimulate Tregs even if patients don't have a
> deficiency (which probably accounts for why tumors use folic acid and
> are vulnerable to these antibodies). =A0This may mean folic acid is a goo=
d
> general treatment for autoimmune disorders.
>
> Serum folic acid in general can be affected by autoimmune diseases. =A0In
> Celiac disease, the levels of transglutaminase antibodies seem inversely
> correlated to serum folic acid levels [PMID 15861017, 17190764]. =A0Given
> how a serum drop would affect body-wide vitamin D3 levels and the
> chemopreventative role of D3, this may be one reason bowel cancer risk
> goes up in some of these autoimmune diseases. =A0Since estrogen helps
> stimulate expression of the VDR, this may be a set of factors explaining
> why bowel cancer is more common in men [PMID 19450178].
>
> These folate receptor antibodies may be a cause of subfertility risk in
> women [PMID 18950755]. =A0They have been associated with high milk
> consumption [PMID 19282368] and a milk-free diet can help reduce the
> autoantibodies [PMID 18355335]. =A0Given the role opioids play regulating
> antibody production in B-cells [PMID 18387505], I have to wonder if this
> cross-reaction to folate receptors caused by consuming cow's milk might
> stem from the molecular similarities between the casein in milk and
> opioids.
>
> Given that my folinic acid supply will be sporadic for a while, does
> anybody know where I can find an inexpensive, high dose folate
> supplement - somewhere on the order of 10mg a day?