Folic acid receptor autoantibodies, vitamin D3 and milk consumption in autoimmune disease - alt.support.sinusitis

Message from discussion Folic acid receptor autoantibodies, vitamin D3 and milk consumption in autoimmune disease

Robert Miles

More options Jun 2, 5:01 pm

Newsgroups: alt.support.sinusitis, alt.support.celiac, alt.support.crohns-colitis, sci.med.immunology, alt.med.fibromyalgia

From: "Robert Miles" <robertmi...@bellsouthNOSPAM.net>

Date: Tue, 2 Jun 2009 02:01:35 -0500

Local: Tues, Jun 2 2009 5:01 pm

Subject: Re: Folic acid receptor autoantibodies, vitamin D3 and milk consumption in autoimmune disease

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"Kofi" <k...@anon.un> wrote in message

news:kofi-5081C9.01541301062009@news.west.earthlink.net...

> The FDA suspended manufacture of leucovorin (folinic acid) due to
> quality issues in early March and since then, I've been off it and doing
> rather poorly. Supposedly production has resumed, but I've only been
> able to get one bottle. It's lasted about a week. Since folinic acid
> has become key in a number of chemotherapies, its availability may
> remain limited for a while.

[snip]
> It also turns out that low folic acid levels lead to higher vitamin D3
> catabolism [PMID 19450178] so if the CNS is deficient in folic acid,
> vitamin D3 isn't going to function properly - leading to a drop in redox
> capacity (e.g., low glutathione)/metals detoxification/neurogenesis,
> loss of antiviral functions/cathelicidin, increased cancer risk and
> probably autoimmune issues as well. But it's going to be invisible to
> anybody checking strict serum levels. It makes me wonder if certain
> vital infections don't deliberately stir up anti-folic acid receptor
> antibodies to block the antiviral effects of vitamin D3 within the
> nervous system itself.

[snip]
> Given that my folinic acid supply will be sporadic for a while, does
> anybody know where I can find an inexpensive, high dose folate
> supplement - somewhere on the order of 10mg a day?

.
I don't, but I'll pass along a little about what I've found about vitamin
metabolism lately. Vitamin B12 works together with a biochemical
produced from folic acid for some purposes. This suggests that it
may be worthwhile checking if the methylcobalamin form of vitamin
B12 (the only form able to enter the brain, and normally produced
in a few steps from the cyanocobalamin form normally used for
vitamin B12 supplements in the US) offers you any help in using
folic acid or folinic acid more efficiently, and therefore decreasing
the amount you need.

<http://www.webmd.com/a-to-z-guides/vitamin-b12-deficiency-anemia-topi...>

http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12/

<http://www.mayoclinic.com/health/vitamin-deficiency-anemia/DS00325/DS...>

Although methylcobalamin is available as a supplement, some
people have enough trouble absorbing any form of vitamin B12
that they need it delivered as injections. Since it's the normal
form of vitamin B12 supplements in Japan, looking for a Japanese
vitamin company may help.

I believe I've seen the brand name Methyl-B12 as one possibility.

Some information on vitamin B9, usually taken in the folic acid
form if you don't get enough from the folic acid added to most
bread:

http://www.spineuniverse.com/displayarticle.php/article963.html

http://www.drweil.com/drw/u/ART02809/vitamin-b9-folate.html

http://www.umm.edu/altmed/articles/vitamin-b9-000338.htm

I've forgotten the full name of the form of vitamin B9 which
can enter the brain, but I believe it includes tetrahydrofolate.

http://en.wikipedia.org/wiki/Tetrahydrofolate

http://en.wikipedia.org/wiki/Folic_acid

http://www.biocheminfo.org/klotho/html/tetrahydrofolate.html

<http://biocyc.org/META/NEW-IMAGE?type=COMPOUND&object=THF>

http://www.ncbi.nlm.nih.gov/pubmed/11752472

http://biocyc.org/META/new-image?object=FOLSYN-PWY

http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000672

http://www.nd.edu/~aseriann/thf.html

Vitamin D3 is closer to the form of vitamin D that the body
actually uses than the vitamin D2 form often used for vitamin D
supplements. Vitamin D is better absorbed if taken along with
some oil; therefore the forms of vitamin D3 already dissolved
in oil are especially active.

Robert Miles

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