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Folic acid receptor autoantibodies, vitamin D3 and milk consumption in autoimmune disease
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From: Pramesh Rutaji <p297tongue6...@newsguy.com>
Newsgroups: alt.baldspot,sci.life-extension,alt.support.food-allergies,alt.support.ibs
Subject: Re: Folic acid receptor autoantibodies, vitamin D3 and milk consumption
in autoimmune disease
Date: Mon, 01 Jun 2009 09:30:56 -0600
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Kofi wrote:
> The FDA suspended manufacture of leucovorin (folinic acid) due to=20
> quality issues in early March and since then, I've been off it and doin=
g=20
> rather poorly. Supposedly production has resumed, but I've only been=20
> able to get one bottle. It's lasted about a week. Since folinic acid =
> has become key in a number of chemotherapies, its availability may=20
> remain limited for a while.
>=20
> Now that I'm back on it, it's like somebody turned on the vitamin D=20
> spigot again. The results have been so dramatic it prompted me to dig =
> deeper. It turns out regulatory T-cells have folic acid receptors [PMI=
D=20
> 17613255] and certain autoimmune patients and low-functioning autistics=
=20
> [PMID 18461502] generate autoantibodies against folic acid receptors - =
> quite possibly as the aftereffect of clearing out a viral infection or =
a=20
> cancer that trained B-cells to target the receptor.
>=20
> If these folic acid receptor antibodies are numerous enough, they can=20
> block entry of folic acid into the central nervous system. The recepto=
r=20
> is necessary for folic acid to cross the blood-brain barrier. A patien=
t=20
> with normal serum folic acid levels might actually be deficient in the =
> CNS which would only show up in a tap - a procedure doctors rarely=20
> perform.
>=20
> It also turns out that low folic acid levels lead to higher vitamin D3 =
> catabolism [PMID 19450178] so if the CNS is deficient in folic acid,=20
> vitamin D3 isn't going to function properly - leading to a drop in redo=
x=20
> capacity (e.g., low glutathione)/metals detoxification/neurogenesis,=20
> loss of antiviral functions/cathelicidin, increased cancer risk and=20
> probably autoimmune issues as well. But it's going to be invisible to =
> anybody checking strict serum levels. It makes me wonder if certain=20
> vital infections don't deliberately stir up anti-folic acid receptor=20
> antibodies to block the antiviral effects of vitamin D3 within the=20
> nervous system itself.
>=20
> The upside, though, is that supplementing with folinic acid shots or a =
> high dose oral folic acid seems to restore CNS levels [PMID 19260931]. =
=20
> Folic acid per se may stimulate Tregs even if patients don't have a=20
> deficiency (which probably accounts for why tumors use folic acid and=20
> are vulnerable to these antibodies). This may mean folic acid is a goo=
d=20
> general treatment for autoimmune disorders.
>=20
> Serum folic acid in general can be affected by autoimmune diseases. In=
=20
> Celiac disease, the levels of transglutaminase antibodies seem inversel=
y=20
> correlated to serum folic acid levels [PMID 15861017, 17190764]. Given=
=20
> how a serum drop would affect body-wide vitamin D3 levels and the=20
> chemopreventative role of D3, this may be one reason bowel cancer risk =
> goes up in some of these autoimmune diseases. Since estrogen helps=20
> stimulate expression of the VDR, this may be a set of factors explainin=
g=20
> why bowel cancer is more common in men [PMID 19450178].
>=20
> These folate receptor antibodies may be a cause of subfertility risk in=
=20
> women [PMID 18950755]. They have been associated with high milk=20
> consumption [PMID 19282368] and a milk-free diet can help reduce the=20
> autoantibodies [PMID 18355335]. Given the role opioids play regulating=
=20
> antibody production in B-cells [PMID 18387505], I have to wonder if thi=
s=20
> cross-reaction to folate receptors caused by consuming cow's milk might=
=20
> stem from the molecular similarities between the casein in milk and=20
> opioids.
>=20
> Given that my folinic acid supply will be sporadic for a while, does=20
> anybody know where I can find an inexpensive, high dose folate=20
> supplement - somewhere on the order of 10mg a day?
http://www.easycart.net/BeyondACenturyInc./Vitamins.html#1119
A scale scale is needed to measure this out. The product is mixed with=20
TMG (10% folic acid, 90% TMG) so a dose of 100 mg will give you 10 mg of =
folic acid. You get 3 grams of folic acid for only $4 USD or 300 doses=20
at the 10 mg/daily you're interested in.
Also, look up l-methylfolate. There are prescription combinations that=20
have this ingredient. It used to be over the counter since it is found=20
naturally but somehow someone got a use patient or thereabouts and=20
pulled the stuff a couple of years ago.
http://en.wikipedia.org/wiki/L-methylfolate
http://en.wikipedia.org/wiki/Category:Folates
DEPLIN
METANX
Cerefolin
N=E9evo
Zervalx
--=20
Pramesh Rutaji
p297tongue6...@newsguy.com - remove tongue to reply
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