Confirmation that OCTN2 is downregulated in IBDs - alt.support.food-allergies

Message from discussion Confirmation that OCTN2 is downregulated in IBDs
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From: jay <jaym1...@hotmail.com>
Newsgroups: sci.life-extension,alt.support.food-allergies,alt.support.ibs,alt.support.celiac,alt.support.crohns-colitis
Subject: Re: Confirmation that OCTN2 is downregulated in IBDs
Date: Sat, 20 Jun 2009 11:50:13 -0700 (PDT)
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> OCTN2 is upregulated by intermittent fasting, exercise, PPARalpha
> agonists and, I think, testosterone. =A0It's vital for carnitine uptake
> (which is antiinflammatory in the gut) and butyrate metabolism (crucial
> for HDAC inhibition).
> =A0
> Changes in mRNA expression levels of solute carrier transporters in
> inflammatory bowel disease patients...

Does the study distinguish if OCTN2 (carnitine transporter) reduction
causes IBD or that OCTN2 is simply reduced during inflammation? Since
carnitine is an antioxidant and is essential for metabolism of long
chain fatty acids (LCFAs), lack of it could cause inflammation. On the
other hand, during inflammation, cell many not want to metabolize
LCFAs since they are prone to peroxidation.