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Newsgroups: sci.life-extension, alt.support.food-allergies, alt.support.ibs, alt.support.celiac, alt.support.crohns-colitis
From: jay <jaym1...@hotmail.com>
Date: Sat, 20 Jun 2009 11:50:13 -0700 (PDT)
Local: Sun, Jun 21 2009 4:50 am
Subject: Re: Confirmation that OCTN2 is downregulated in IBDs
> OCTN2 is upregulated by intermittent fasting, exercise, PPARalpha Does the study distinguish if OCTN2 (carnitine transporter) reduction > agonists and, I think, testosterone. It's vital for carnitine uptake > (which is antiinflammatory in the gut) and butyrate metabolism (crucial > for HDAC inhibition). > > Changes in mRNA expression levels of solute carrier transporters in > inflammatory bowel disease patients... causes IBD or that OCTN2 is simply reduced during inflammation? Since carnitine is an antioxidant and is essential for metabolism of long chain fatty acids (LCFAs), lack of it could cause inflammation. On the other hand, during inflammation, cell many not want to metabolize LCFAs since they are prone to peroxidation. You must Sign in before you can post messages.
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