Confirmation that OCTN2 is downregulated in IBDs - alt.support.food-allergies

Message from discussion Confirmation that OCTN2 is downregulated in IBDs
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From: Kofi <k...@anon.un>
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Subject: Confirmation that OCTN2 is downregulated in IBDs
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OCTN2 is upregulated by intermittent fasting, exercise, PPARalpha 
agonists and, I think, testosterone.  It's vital for carnitine uptake 
(which is antiinflammatory in the gut) and butyrate metabolism (crucial 
for HDAC inhibition).

Drug Metab Dispos. 2009 Jun 1; 
 
Changes in mRNA expression levels of solute carrier transporters in 
inflammatory bowel disease patients.
Wojtal KA, Eloranta JJ, Hruz P, Gutmann H, Drewe J, Beglinger C, Fried 
M, Kullak-Ublick GA, Vavricka SR.
University Hospital Zurich.

Inflammatory bowel disease (IBD) is an inflammatory condition that 
affects gastrointestinal tract. Solute carrier superfamilly of 
transporters (SLC) comprise proteins involved in the uptake of drugs, 
hormones, and other biologically active compounds. The purpose of this 
study was to determine the mRNA expression levels of 15 solute carrier 
transporters in two regions of the intestine in IBD patients. Endoscopic 
biopsies were taken from two locations (terminal ileum and colon) for 
histological examination and RNA extraction. We quantitatively measured 
the mRNA expression of 15 SLC transporters in 107 IBD patients (53 
Crohn's disease and 54 ulcerative colitis) and 23 control subjects. 
Messenger RNA expression was evaluated using the quantitative reverse 
transciption-PCR technique. We observed that in ileum of IBD patients, 
mRNA levels for SERT, ENT1, ENT2, and OATP2B1 were significantly 
elevated while for ASBT and OCTN2 they were significantly lower. In 
colon, mRNA levels for ENT1, ENT2, CNT2, OATP2B1, and OATP4A1 were 
significantly higher, while mRNA levels for OCTN2 were significantly 
decreased. In inflamed colon of IBD patients the mRNA expression levels 
of ENT1, ENT2, CNT2, OATP2B1, OATP4A1, and PEPT1 were significantly 
higher. We conclude that intestinal SLC mRNA levels are dysregulated in 
IBD patients, which may be linked to the inflammation of the tissue and 
provides an indication about the role of inflammatory signalling in 
regulation of SLC expression.

PMID: 19487253