Kofi <k...@anon.un>

OCTN2 is upregulated by intermittent fasting, exercise, PPARalpha
agonists and, I think, testosterone.  It's vital for carnitine uptake
(which is antiinflammatory in the gut) and butyrate metabolism (crucial
for HDAC inhibition).

Drug Metab Dispos. 2009 Jun 1;
 
Changes in mRNA expression levels of solute carrier transporters in
inflammatory bowel disease patients.
Wojtal KA, Eloranta JJ, Hruz P, Gutmann H, Drewe J, Beglinger C, Fried
M, Kullak-Ublick GA, Vavricka SR.
University Hospital Zurich.

Inflammatory bowel disease (IBD) is an inflammatory condition that
affects gastrointestinal tract. Solute carrier superfamilly of
transporters (SLC) comprise proteins involved in the uptake of drugs,
hormones, and other biologically active compounds. The purpose of this
study was to determine the mRNA expression levels of 15 solute carrier
transporters in two regions of the intestine in IBD patients. Endoscopic
biopsies were taken from two locations (terminal ileum and colon) for
histological examination and RNA extraction. We quantitatively measured
the mRNA expression of 15 SLC transporters in 107 IBD patients (53
Crohn's disease and 54 ulcerative colitis) and 23 control subjects.
Messenger RNA expression was evaluated using the quantitative reverse
transciption-PCR technique. We observed that in ileum of IBD patients,
mRNA levels for SERT, ENT1, ENT2, and OATP2B1 were significantly
elevated while for ASBT and OCTN2 they were significantly lower. In
colon, mRNA levels for ENT1, ENT2, CNT2, OATP2B1, and OATP4A1 were
significantly higher, while mRNA levels for OCTN2 were significantly
decreased. In inflamed colon of IBD patients the mRNA expression levels
of ENT1, ENT2, CNT2, OATP2B1, OATP4A1, and PEPT1 were significantly
higher. We conclude that intestinal SLC mRNA levels are dysregulated in
IBD patients, which may be linked to the inflammation of the tissue and
provides an indication about the role of inflammatory signalling in
regulation of SLC expression.

PMID: 19487253