Message from discussion Folic acid receptor autoantibodies, vitamin D3 and milk consumption in autoimmune disease

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Subject: Re: Folic acid receptor autoantibodies, vitamin D3 and milk 
	consumption in autoimmune disease
Date: Mon, 1 Jun 2009 08:20:32 -0700 (PDT)
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On 1 Jun., 09:54, Kofi <k...@anon.un> wrote:
> The FDA suspended manufacture of leucovorin (folinic acid) due to
> quality issues in early March and since then, I've been off it and doing
> rather poorly. =A0Supposedly production has resumed, but I've only been
> able to get one bottle. =A0It's lasted about a week. =A0Since folinic aci=
d
> has become key in a number of chemotherapies, its availability may
> remain limited for a while.
>
> Now that I'm back on it, it's like somebody turned on the vitamin D
> spigot again. =A0The results have been so dramatic it prompted me to dig
> deeper. =A0It turns out regulatory T-cells have folic acid receptors [PMI=
D
> 17613255] and certain autoimmune patients and low-functioning autistics
> [PMID 18461502] generate autoantibodies against folic acid receptors -
> quite possibly as the aftereffect of clearing out a viral infection or a
> cancer that trained B-cells to target the receptor.
>
> If these folic acid receptor antibodies are numerous enough, they can
> block entry of folic acid into the central nervous system. =A0The recepto=
r
> is necessary for folic acid to cross the blood-brain barrier. =A0A patien=
t
> with normal serum folic acid levels might actually be deficient in the
> CNS which would only show up in a tap - a procedure doctors rarely
> perform.
>
> It also turns out that low folic acid levels lead to higher vitamin D3
> catabolism [PMID 19450178] so if the CNS is deficient in folic acid,
> vitamin D3 isn't going to function properly - leading to a drop in redox
> capacity (e.g., low glutathione)/metals detoxification/neurogenesis,
> loss of antiviral functions/cathelicidin, increased cancer risk and
> probably autoimmune issues as well. =A0But it's going to be invisible to
> anybody checking strict serum levels. =A0It makes me wonder if certain
> vital infections don't deliberately stir up anti-folic acid receptor
> antibodies to block the antiviral effects of vitamin D3 within the
> nervous system itself.
>
> The upside, though, is that supplementing with folinic acid shots or a
> high dose oral folic acid seems to restore CNS levels [PMID 19260931]. =
=A0
> Folic acid per se may stimulate Tregs even if patients don't have a
> deficiency (which probably accounts for why tumors use folic acid and
> are vulnerable to these antibodies). =A0This may mean folic acid is a goo=
d
> general treatment for autoimmune disorders.
>
> Serum folic acid in general can be affected by autoimmune diseases. =A0In
> Celiac disease, the levels of transglutaminase antibodies seem inversely
> correlated to serum folic acid levels [PMID 15861017, 17190764]. =A0Given
> how a serum drop would affect body-wide vitamin D3 levels and the
> chemopreventative role of D3, this may be one reason bowel cancer risk
> goes up in some of these autoimmune diseases. =A0Since estrogen helps
> stimulate expression of the VDR, this may be a set of factors explaining
> why bowel cancer is more common in men [PMID 19450178].
>
> These folate receptor antibodies may be a cause of subfertility risk in
> women [PMID 18950755]. =A0They have been associated with high milk
> consumption [PMID 19282368] and a milk-free diet can help reduce the
> autoantibodies [PMID 18355335]. =A0Given the role opioids play regulating
> antibody production in B-cells [PMID 18387505], I have to wonder if this
> cross-reaction to folate receptors caused by consuming cow's milk might
> stem from the molecular similarities between the casein in milk and
> opioids.
>
> Given that my folinic acid supply will be sporadic for a while, does
> anybody know where I can find an inexpensive, high dose folate
> supplement - somewhere on the order of 10mg a day?

It'll be very hard to find a supplement with more than 1 mg.

2.53$ for 100 tablets with 800mcg by Natures way
http://www.vitacost.com/Natures-Way-Folic-Acid

Tetrahydrofolate 800 mcg, 120 tablets for 32$. Since it's the active
form you should need less of it.
http://www.naturalhealthyconcepts.com/folapro-p-metagenics.html