> I am just wondering if anyone has experienced muscle twitching when your > Crohns is flaring?
I'll skip the footnotes.
Magnesium deficiency should be at the top of your suspect list. I had severe muscle twitching until I started taking magnesium. If this is the cause of your problem, it's probably a disturbance in your TRPM transporters either in the gut or kidneys. It's vital you take magnesium with calcium and phosphorus for good absorption - but this won't necessarily help you retain it if the transporters in your kidney are boxed.
As far as the transporters go, you need adequate intakes or levels of vitamin D3, omega 3 fish oils and inulin (which may ultimately indicate butyrate) to make them work properly.
Cyclosporine A and other drugs that knock down c-Fos or EGF expression in the gut (green tea and curcumin fall into this camp) tend to inhibit magnesium absorption. Interfering with aldosterone, ACE or angiotensin II might also do that.
Estrogen deficiency can cause magnesium deficiency. There's good evidence DHEA deficiency might cause it too - pointing to a general need for proper sympathoadrenal tone (i.e., good function in your adrenal glands). I'm working on a paper now about that.
Oddly, some food dyes can interfere with vitamin D3 in the gut. Brilliant Blue G blocks the cathlicidin receptor P2X7 and that then would block EGF which you need for magnesium absorption and gut barrier function.
I think acetyl-l-carnitine is an excellent suggestion. It can, however, directly stoke your neurotrophins which then affects cancer risk (raising it for some, lowering it for others) and, of course, it sends hair follicles into premature catagen. So high doses of ALCAR (~ 3g/daily) might cause hair loss and/or brain tumors. Then again, magnesium deficiency is no picnic either. It raises substance P levels which then exacerbates neuropathy and allergic inflammation (which should also cause hair loss through excessive mast cell degranulation). Other carnitines might accomplish the same goal without the same side effects.
FYI, magnesium deficiency is a contributor to obesity, hypertension and other metabolic diseases.
> > FYI, magnesium deficiency is a contributor to obesity, hypertension and > > other metabolic diseases.
> Kofi,
> What is the best form of magnesium to supplement with?
> Ever heard of Natural Calm? Do you think it is worth the extra $$$, or > are their claims just marketing hype?
> TIA, > Dave
I am not Kofi but I'll offer a comment or two. I'd avoid magnesium oxide as it rather low availability. Magnesium carbonate as I recall is pretty soluble so it should be good. A really low cost source is epsoms salts which is magnesium sulfate plus the waters of hydration. It is highly soluble though you'll need to keep the magnesium doses down around a couple hundred milligrams. An 1/8 of teaspoonful should be OK as I dimly recall. More will loosen the stool. It has been a long time since I've use the latter. Plus if you take other powders that can loosen the stool this can be an issue again by way of an additive effect.
I also have a rather inferior product on my counter that was supposedly magnesium ascorbate but is really vitamin C crystals with magnesium oxide. I can let this stand after I dissolve it in water and the oxide never full dissolves to neutralize the acidity.
In article <41c8c01d-a987-4353-9a60-8abe7ec27...@l31g2000vbp.googlegroups.com>,
Beez <bea...@yahoo.com> wrote: > On Aug 6, 12:06 pm, Kofi <k...@anon.un> wrote: > > FYI, magnesium deficiency is a contributor to obesity, hypertension and > > other metabolic diseases.
> Kofi,
> What is the best form of magnesium to supplement with?
I don't know. If nothing else works, you can try I.M. shots.
Beez wrote: > On Aug 6, 12:06 pm, Kofi <k...@anon.un> wrote: >> FYI, magnesium deficiency is a contributor to obesity, hypertension and >> other metabolic diseases.
> Kofi,
> What is the best form of magnesium to supplement with?
> Ever heard of Natural Calm? Do you think it is worth the extra $$$, or > are their claims just marketing hype?
> TIA, > Dave
Magnesium Citrate is very well absorbed. Try a website like:
>> What is the best form of magnesium to supplement with? > I don't know. If nothing else works, you can try I.M. shots.
Cheapest is Epsom salt. If taking it orally doesn't work, bath in it. Epsom salt baths are often used for treating autism.
==== j a c k at c a m p i n . m e . u k === <http://www.campin.me.uk> ==== Jack Campin, 11 Third St, Newtongrange EH22 4PU, Scotland == mob 07800 739 557 CD-ROMs and free stuff: Scottish music, food intolerance, and Mac logic fonts ****** I killfile Google posts - email me if you want to be whitelisted ******
>> I am just wondering if anyone has experienced muscle twitching when your >> Crohns is flaring?
> I'll skip the footnotes.
> Magnesium deficiency should be at the top of your suspect list. I had > severe muscle twitching until I started taking magnesium. If this is > the cause of your problem, it's probably a disturbance in your TRPM > transporters either in the gut or kidneys. It's vital you take > magnesium with calcium and phosphorus for good absorption - but this > won't necessarily help you retain it if the transporters in your kidney > are boxed.
> As far as the transporters go, you need adequate intakes or levels of > vitamin D3, omega 3 fish oils and inulin (which may ultimately indicate > butyrate) to make them work properly.
> Cyclosporine A and other drugs that knock down c-Fos or EGF expression > in the gut (green tea and curcumin fall into this camp) tend to inhibit > magnesium absorption. Interfering with aldosterone, ACE or angiotensin > II might also do that.
> Estrogen deficiency can cause magnesium deficiency. There's good > evidence DHEA deficiency might cause it too - pointing to a general need > for proper sympathoadrenal tone (i.e., good function in your adrenal > glands). I'm working on a paper now about that.
> Oddly, some food dyes can interfere with vitamin D3 in the gut. > Brilliant Blue G blocks the cathlicidin receptor P2X7 and that then > would block EGF which you need for magnesium absorption and gut barrier > function.
> I think acetyl-l-carnitine is an excellent suggestion. It can, however, > directly stoke your neurotrophins which then affects cancer risk > (raising it for some, lowering it for others) and, of course, it sends > hair follicles into premature catagen. So high doses of ALCAR (~ > 3g/daily) might cause hair loss and/or brain tumors. Then again, > magnesium deficiency is no picnic either. It raises substance P levels > which then exacerbates neuropathy and allergic inflammation (which > should also cause hair loss through excessive mast cell degranulation). > Other carnitines might accomplish the same goal without the same side > effects.
> FYI, magnesium deficiency is a contributor to obesity, hypertension and > other metabolic diseases.
In article <9e21ff35-6208-450e-a7f9-e1bf33eda...@k13g2000prh.googlegroups.com>,
flamesrock <flamesr...@gmail.com> wrote: > Kofi, I thought ALCAR was supposed to improve hair growth. Could you > clarify?
> -thanks in advance
As I've pointed out in old articles, long-term use of acetyl-l-carnitine regenerates peripheral nerves by upregulating the p75 low-affinity nerve growth factor receptor. p75 is involved in cross-talk between hair follicles and mast cells during the process of catagen.
Magnesium blood tests are fairly unreliable since levels fluctuate a lot. (As I dimly recall from various readings. I may be mistaken on this particular point.)
Magnesium is recycled by the kidneys. Many common diuretics can result in magnesium deficiency. (e.g. HCT.)
Magnesium is important for the chlorophyll process. Rich nutrient sources include green leafy vegetables, seeds, and nuts.
Magnesium, it used to be written, should be around half as much in the diet as calcium. (So for example if you are getting 1000 milligrams daily of calcium, by that general rule you should be getting 500 milligrams of magnesium.) The suggested ratio varies from author to author and frankly I haven't seen anything specific in the research literature, though I haven't gone looking for it either. My suspicion has been for a couple of decades that taking large amounts of calcium supplements can artificially induce a magnesium deficiency. Does anyone know more on this? Preferably with sources that are peer-reviewed and can be cited?
FWIW, (pasted from a very quick google search)... Mineral Ratios for Calcium, Magnesium & other ElementsMost standard Calcium / Magnesium formulations are sold in a ratio of 2:1, .... a patient's calcium / magnesium ratio. Other types of anxiety, fatigue, ... www.acu-cell.com/mr.html - Cached - Similar
Richard H.
On Aug 7, 4:57 pm, "Are you kidding" <no...@nowhere.com> wrote:
> >> I am just wondering if anyone has experienced muscle twitching when your > >> Crohns is flaring?
> > I'll skip the footnotes.
> > Magnesium deficiency should be at the top of your suspect list. I had > > severe muscle twitching until I started taking magnesium. If this is > > the cause of your problem, it's probably a disturbance in your TRPM > > transporters either in the gut or kidneys. It's vital you take > > magnesium with calcium and phosphorus for good absorption - but this > > won't necessarily help you retain it if the transporters in your kidney > > are boxed.
> > As far as the transporters go, you need adequate intakes or levels of > > vitamin D3, omega 3 fish oils and inulin (which may ultimately indicate > > butyrate) to make them work properly.
> > Cyclosporine A and other drugs that knock down c-Fos or EGF expression > > in the gut (green tea and curcumin fall into this camp) tend to inhibit > > magnesium absorption. Interfering with aldosterone, ACE or angiotensin > > II might also do that.
> > Estrogen deficiency can cause magnesium deficiency. There's good > > evidence DHEA deficiency might cause it too - pointing to a general need > > for proper sympathoadrenal tone (i.e., good function in your adrenal > > glands). I'm working on a paper now about that.
> > Oddly, some food dyes can interfere with vitamin D3 in the gut. > > Brilliant Blue G blocks the cathlicidin receptor P2X7 and that then > > would block EGF which you need for magnesium absorption and gut barrier > > function.
> > I think acetyl-l-carnitine is an excellent suggestion. It can, however, > > directly stoke your neurotrophins which then affects cancer risk > > (raising it for some, lowering it for others) and, of course, it sends > > hair follicles into premature catagen. So high doses of ALCAR (~ > > 3g/daily) might cause hair loss and/or brain tumors. Then again, > > magnesium deficiency is no picnic either. It raises substance P levels > > which then exacerbates neuropathy and allergic inflammation (which > > should also cause hair loss through excessive mast cell degranulation). > > Other carnitines might accomplish the same goal without the same side > > effects.
> > FYI, magnesium deficiency is a contributor to obesity, hypertension and > > other metabolic diseases.- Hide quoted text -
Trouble with all that ratio stuff is they are based on content of one part of your body (bone structure) and not required intake ratios / absorption rates.
"harpersnotes" <harpersno...@gmail.com> wrote in message
Magnesium blood tests are fairly unreliable since levels fluctuate a lot. (As I dimly recall from various readings. I may be mistaken on this particular point.)
Magnesium is recycled by the kidneys. Many common diuretics can result in magnesium deficiency. (e.g. HCT.)
Magnesium is important for the chlorophyll process. Rich nutrient sources include green leafy vegetables, seeds, and nuts.
Magnesium, it used to be written, should be around half as much in the diet as calcium. (So for example if you are getting 1000 milligrams daily of calcium, by that general rule you should be getting 500 milligrams of magnesium.) The suggested ratio varies from author to author and frankly I haven't seen anything specific in the research literature, though I haven't gone looking for it either. My suspicion has been for a couple of decades that taking large amounts of calcium supplements can artificially induce a magnesium deficiency. Does anyone know more on this? Preferably with sources that are peer-reviewed and can be cited?
FWIW, (pasted from a very quick google search)... Mineral Ratios for Calcium, Magnesium & other ElementsMost standard Calcium / Magnesium formulations are sold in a ratio of 2:1, .... a patient's calcium / magnesium ratio. Other types of anxiety, fatigue, ... www.acu-cell.com/mr.html - Cached - Similar
Richard H.
On Aug 7, 4:57 pm, "Are you kidding" <no...@nowhere.com> wrote:
> >> I am just wondering if anyone has experienced muscle twitching when > >> your > >> Crohns is flaring?
> > I'll skip the footnotes.
> > Magnesium deficiency should be at the top of your suspect list. I had > > severe muscle twitching until I started taking magnesium. If this is > > the cause of your problem, it's probably a disturbance in your TRPM > > transporters either in the gut or kidneys. It's vital you take > > magnesium with calcium and phosphorus for good absorption - but this > > won't necessarily help you retain it if the transporters in your kidney > > are boxed.
> > As far as the transporters go, you need adequate intakes or levels of > > vitamin D3, omega 3 fish oils and inulin (which may ultimately indicate > > butyrate) to make them work properly.
> > Cyclosporine A and other drugs that knock down c-Fos or EGF expression > > in the gut (green tea and curcumin fall into this camp) tend to inhibit > > magnesium absorption. Interfering with aldosterone, ACE or angiotensin > > II might also do that.
> > Estrogen deficiency can cause magnesium deficiency. There's good > > evidence DHEA deficiency might cause it too - pointing to a general need > > for proper sympathoadrenal tone (i.e., good function in your adrenal > > glands). I'm working on a paper now about that.
> > Oddly, some food dyes can interfere with vitamin D3 in the gut. > > Brilliant Blue G blocks the cathlicidin receptor P2X7 and that then > > would block EGF which you need for magnesium absorption and gut barrier > > function.
> > I think acetyl-l-carnitine is an excellent suggestion. It can, however, > > directly stoke your neurotrophins which then affects cancer risk > > (raising it for some, lowering it for others) and, of course, it sends > > hair follicles into premature catagen. So high doses of ALCAR (~ > > 3g/daily) might cause hair loss and/or brain tumors. Then again, > > magnesium deficiency is no picnic either. It raises substance P levels > > which then exacerbates neuropathy and allergic inflammation (which > > should also cause hair loss through excessive mast cell degranulation). > > Other carnitines might accomplish the same goal without the same side > > effects.
> > FYI, magnesium deficiency is a contributor to obesity, hypertension and > > other metabolic diseases.- Hide quoted text -
> In article > <9e21ff35-6208-450e-a7f9-e1bf33eda...@k13g2000prh.googlegroups.com>,
> flamesrock<flamesr...@gmail.com> wrote: > > Kofi, I thought ALCAR was supposed to improve hair growth. Could you > > clarify?
> > -thanks in advance
> As I've pointed out in old articles, long-term use of acetyl-l-carnitine > regenerates peripheral nerves by upregulating the p75 low-affinity nerve > growth factor receptor. p75 is involved in cross-talk between hair > follicles and mast cells during the process of catagen.
> Trouble with all that ratio stuff is they are based on content of one part > of your body (bone structure) and not required intake ratios / absorption > rates.
> "harpersnotes" <harpersno...@gmail.com> wrote in message
> Magnesium blood tests are fairly unreliable since levels fluctuate a > lot. > (As I dimly recall from various readings. I may be mistaken on this > particular point.)
> Magnesium is recycled by the kidneys. > Many common diuretics can result in magnesium deficiency. (e.g. HCT.)
> Magnesium is important for the chlorophyll process. > Rich nutrient sources include green leafy vegetables, seeds, and > nuts.
> Magnesium, it used to be written, should be around half as much in the > diet > as calcium. (So for example if you are getting 1000 milligrams daily > of calcium, by that > general rule you should be getting 500 milligrams of magnesium.) The > suggested ratio > varies from author to author and frankly I haven't seen anything > specific in the research > literature, though I haven't gone looking for it either. My suspicion > has been for a couple > of decades that taking large amounts of calcium supplements can > artificially induce a > magnesium deficiency. Does anyone know more on this? Preferably with > sources that > are peer-reviewed and can be cited?
> FWIW, (pasted from a very quick google search)... > Mineral Ratios for Calcium, Magnesium & other ElementsMost standard > Calcium / Magnesium formulations are sold in a ratio of 2:1, .... a > patient's calcium / magnesium ratio. Other types of anxiety, > fatigue, ...www.acu-cell.com/mr.html- Cached - Similar
> Richard H.
> On Aug 7, 4:57 pm, "Are you kidding" <no...@nowhere.com> wrote:
> > Thank you for the information. Is a magnesium deficiency something they > > can > > test for?
> > >> I am just wondering if anyone has experienced muscle twitching when > > >> your > > >> Crohns is flaring?
> > > I'll skip the footnotes.
> > > Magnesium deficiency should be at the top of your suspect list. I had > > > severe muscle twitching until I started taking magnesium. If this is > > > the cause of your problem, it's probably a disturbance in your TRPM > > > transporters either in the gut or kidneys. It's vital you take > > > magnesium with calcium and phosphorus for good absorption - but this > > > won't necessarily help you retain it if the transporters in your kidney > > > are boxed.
> > > As far as the transporters go, you need adequate intakes or levels of > > > vitamin D3, omega 3 fish oils and inulin (which may ultimately indicate > > > butyrate) to make them work properly.
> > > Cyclosporine A and other drugs that knock down c-Fos or EGF expression > > > in the gut (green tea and curcumin fall into this camp) tend to inhibit > > > magnesium absorption. Interfering with aldosterone, ACE or angiotensin > > > II might also do that.
> > > Estrogen deficiency can cause magnesium deficiency. There's good > > > evidence DHEA deficiency might cause it too - pointing to a general need > > > for proper sympathoadrenal tone (i.e., good function in your adrenal > > > glands). I'm working on a paper now about that.
> > > Oddly, some food dyes can interfere with vitamin D3 in the gut. > > > Brilliant Blue G blocks the cathlicidin receptor P2X7 and that then > > > would block EGF which you need for magnesium absorption and gut barrier > > > function.
> > > I think acetyl-l-carnitine is an excellent suggestion. It can, however, > > > directly stoke your neurotrophins which then affects cancer risk > > > (raising it for some, lowering it for others) and, of course, it sends > > > hair follicles into premature catagen. So high doses of ALCAR (~ > > > 3g/daily) might cause hair loss and/or brain tumors. Then again, > > > magnesium deficiency is no picnic either. It raises substance P levels > > > which then exacerbates neuropathy and allergic inflammation (which > > > should also cause hair loss through excessive mast cell degranulation). > > > Other carnitines might accomplish the same goal without the same side > > > effects.
> > > FYI, magnesium deficiency is a contributor to obesity, hypertension and > > > other metabolic diseases.- Hide quoted text -
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