SAMe is effective in preventing formation of primary liver cancer in rats July 30th, 2009 A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats. However, high enough levels of SAMe were not attainable to successfully treat established HCC. The findings are available in the August issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.
HCC is the fifth most common cancer and the third most frequent cause of cancer death worldwide. Risk factors for HCC include chronic infection with hepatitis B virus, hepatitis C virus (HCV), dietary aflatoxin, excessive alcohol use, cigarette smoking, diabetes and obesity. The overall 5-year survival for HCC patients is less than 10% and the disease rate is expected to rise due to the high prevalence of HCV in many areas of the world.
Shelly Lu, M.D., of the Keck School of Medicine at the University of Southern California, and colleagues studied the effects of SAMe on chemoprevention and treatment of HCC. In the U.S. the incidence of HCC doubled from 1979 to 1995 and the number of HCC cases for the following 20 to 30 years is projected to increase. "Given these projections, there is a tremendous interest in developing effective chemoprevention strategies," said Dr. Lu. "And an important property of SAMe that makes it an attractive agent for chemoprevention and treatment of HCC is its ability to selectively kill liver cancer cells," she added.
During the study researchers injected H4IIE cells into rats and found a 1cm tumor developed in the liver two weeks after injection. A regimen of IV SAMe was started one day after injecting the cells and continued for ten days. The researchers monitored the animals using MRI, ultrasound, and visual inspection to assess the liver tumors. "Treatment with IV SAMe by continuous infusion significantly reduced the tumor size and significantly prevented tumor development after 11 days," researchers discovered.
Researchers found that if SAMe infusion was started after sizable tumors had already formed it failed to reduce the rate of tumor growth after 24 days of treatment. This is because of a compensatory response of the liver to metabolize SAMe and prevent its accumulation. "The observation that SAMe failed to exert any therapeutic effect in already established HCC is disappointing," said Dr. Lu. "But whether SAMe can be effective in treating HCC in man remains unclear because this compensatory mechanism may not work properly in human HCC. Nevertheless, effectiveness of SAMe in chemoprevention of human HCC deserves study now."
Source: Wiley (news : web)
"Lecithin Raises S-Adenosylmethionine" "Metallothionein might be regulated by the dietary content of methionine" "Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine"
Lecithin is considered to be a method of raising the SAMe in the body and as the SAMe raises metallothionein ..
Sooo .. logically .. the use of lecithin either topically or orally will be an effective method of alleviation of intracerebral hemorrhage or concussion injury from a beating or from the Iraqi .. road .. side .. bombs.
Au Natural
Oil yourself up .. and eat vegetarian . ---------------------------------
Phosphatidyl choline (PC) penetrates effectively throughout the epidermis
Choline-related supplements improve abnormal plasma methionine- homocysteine metabolites and glutathione status in children with cystic fibrosis. Innis SM, Davidson AG, Melynk S, James SJ Am J Clin Nutr 2007 Mar; 85(3):702-8.
BACKGROUND: Liver triacylglycerol accumulation and oxidative stress are common in cystic fibrosis (CF) and also occur in choline deficiency. Previously, we showed an association between elevated plasma homocysteine, reduced ratios of S-adenosylmethionine to S-adenosylhomocysteine (SAM:SAH) and of phosphatidylcholine to phosphatidylethanolamine, and phospholipid malabsorption in children with CF. OBJECTIVE: The objective was to address a possible relation between altered methionine-homocysteine metabolism and choline metabolism in children with CF. DESIGN: Children with CF were assigned without bias to supplementation with 2 g lecithin/d (n = 13), 2 g choline/d (n = 12), or 3 g betaine/ d (n = 10) for 14 d. Plasma concentrations of methionine, adenosine, cysteine, cysteinyl-glycine, glutathione, glutathione disulfide (GSSG), and fatty acids; SAM:SAH; and red blood cell phospholipids were measured within each group of children with CF before and after supplementation. Plasma from healthy children without CF (n = 15) was analyzed to obtain reference data. RESULTS: Children with CF had higher plasma homocysteine, SAH, and adenosine and lower methionine, SAM:SAH, and glutathione:GSSG than did children without CF. Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine, SAM, SAM:SAH, and glutathione:GSSG and a decrease in SAH (n = 35). Supplementation with choline or betaine was associated with a significant decrease in plasma SAH and an increase in SAM:SAH, methionine, and glutathione:GSSG. Supplementation with lecithin or choline also increased plasma methionine and SAM. CONCLUSION: We showed that dietary supplementation with choline-related compounds improves the low SAM:SAH and glutathione redox balance in children with CF.
The American journal of clinical nutrition [Am J Clin Nutr] --------------------------------------------------------------------------- ----- Influence of dietary methionine level on the liver metallothionein mRNA level in rats Auteur(s) / Author(s) KOMANG AYU NOCIANITRI (1) ; SAKAKIBARA Shoji (1) ; KANNO Takashi (2) ; KIKUCHI Hiroto (2) ; KURASAKI Masaaki (3) ; AOYAMA Yoritaka (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s) (1) Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Nishi-9, Kita-9, Kita-ku, Sapporo 060-8589, JAPON (2) Nippon Beet Sugar Mfg. Co. Ltd., Nishi-13, Minami-9, Inada-cho, Obihiro 080-0831, JAPON (3) Graduate School of Environmental Earth Science, Hokkaido University, Nishi-6, Kita-10, Kita-ku, Sapporo 060-0810, JAPON
Résumé / Abstract The effects of some methyl-containing compounds added to a choline- deficient diet on the metallothionein mRNA level in the rat liver were studied. The addition of choline or carnitine to the choline- deficient diet did not induce a gain in body weight, while the addition of either betaine or methionine to the choline-deficient diet, or of methionine to the choline-deficient diet with choline significantly increased the body weight. The metallothionein mRNA level in the liver of rats fed on the choline-deficient diet was similar to that of rats fed on the choline-deficient diet with choline, betaine or carnitine. However, the addition of methionine to the choline-deficient diet with or without choline caused a marked suppression in the metallothionein mRNA level in the liver. It is thus surmised that the metallothionein mRNA level in the liver might be regulated by the dietary content of methionine. Revue / Journal Title Bioscience, biotechnology, and biochemistry ISSN 0916-8451 Source / Source 2002, vol. 66, no11, pp. 2465-2470 [6 page(s) (article)] (31 ref.)
SAMe is effective in preventing formation of primary liver cancer in rats July 30th, 2009 A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats. However, high enough levels of SAMe were not attainable to successfully treat established HCC. The findings are available in the August issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.
HCC is the fifth most common cancer and the third most frequent cause of cancer death worldwide. Risk factors for HCC include chronic infection with hepatitis B virus, hepatitis C virus (HCV), dietary aflatoxin, excessive alcohol use, cigarette smoking, diabetes and obesity. The overall 5-year survival for HCC patients is less than 10% and the disease rate is expected to rise due to the high prevalence of HCV in many areas of the world.
Shelly Lu, M.D., of the Keck School of Medicine at the University of Southern California, and colleagues studied the effects of SAMe on chemoprevention and treatment of HCC. In the U.S. the incidence of HCC doubled from 1979 to 1995 and the number of HCC cases for the following 20 to 30 years is projected to increase. "Given these projections, there is a tremendous interest in developing effective chemoprevention strategies," said Dr. Lu. "And an important property of SAMe that makes it an attractive agent for chemoprevention and treatment of HCC is its ability to selectively kill liver cancer cells," she added.
During the study researchers injected H4IIE cells into rats and found a 1cm tumor developed in the liver two weeks after injection. A regimen of IV SAMe was started one day after injecting the cells and continued for ten days. The researchers monitored the animals using MRI, ultrasound, and visual inspection to assess the liver tumors. "Treatment with IV SAMe by continuous infusion significantly reduced the tumor size and significantly prevented tumor development after 11 days," researchers discovered.
Researchers found that if SAMe infusion was started after sizable tumors had already formed it failed to reduce the rate of tumor growth after 24 days of treatment. This is because of a compensatory response of the liver to metabolize SAMe and prevent its accumulation. "The observation that SAMe failed to exert any therapeutic effect in already established HCC is disappointing," said Dr. Lu. "But whether SAMe can be effective in treating HCC in man remains unclear because this compensatory mechanism may not work properly in human HCC. Nevertheless, effectiveness of SAMe in chemoprevention of human HCC deserves study now."
Source: Wiley (news : web)
"Lecithin Raises S-Adenosylmethionine" "Metallothionein might be regulated by the dietary content of methionine" "Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine"
Lecithin is considered to be a method of raising the SAMe in the body and as the SAMe raises metallothionein ..
Sooo .. logically .. the use of lecithin either topically or orally will be an effective method of alleviation of intracerebral hemorrhage or concussion injury from a beating or from the Iraqi .. road .. side .. bombs.
Au Natural
Oil yourself up .. and eat vegetarian . ---------------------------------
Phosphatidyl choline (PC) penetrates effectively throughout the epidermis
Choline-related supplements improve abnormal plasma methionine- homocysteine metabolites and glutathione status in children with cystic fibrosis. Innis SM, Davidson AG, Melynk S, James SJ Am J Clin Nutr 2007 Mar; 85(3):702-8.
BACKGROUND: Liver triacylglycerol accumulation and oxidative stress are common in cystic fibrosis (CF) and also occur in choline deficiency. Previously, we showed an association between elevated plasma homocysteine, reduced ratios of S-adenosylmethionine to S-adenosylhomocysteine (SAM:SAH) and of phosphatidylcholine to phosphatidylethanolamine, and phospholipid malabsorption in children with CF. OBJECTIVE: The objective was to address a possible relation between altered methionine-homocysteine metabolism and choline metabolism in children with CF. DESIGN: Children with CF were assigned without bias to supplementation with 2 g lecithin/d (n = 13), 2 g choline/d (n = 12), or 3 g betaine/ d (n = 10) for 14 d. Plasma concentrations of methionine, adenosine, cysteine, cysteinyl-glycine, glutathione, glutathione disulfide (GSSG), and fatty acids; SAM:SAH; and red blood cell phospholipids were measured within each group of children with CF before and after supplementation. Plasma from healthy children without CF (n = 15) was analyzed to obtain reference data. RESULTS: Children with CF had higher plasma homocysteine, SAH, and adenosine and lower methionine, SAM:SAH, and glutathione:GSSG than did children without CF. Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine, SAM, SAM:SAH, and glutathione:GSSG and a decrease in SAH (n = 35). Supplementation with choline or betaine was associated with a significant decrease in plasma SAH and an increase in SAM:SAH, methionine, and glutathione:GSSG. Supplementation with lecithin or choline also increased plasma methionine and SAM. CONCLUSION: We showed that dietary supplementation with choline-related compounds improves the low SAM:SAH and glutathione redox balance in children with CF.
The American journal of clinical nutrition [Am J Clin Nutr] --------------------------------------------------------------------------- ----- Influence of dietary methionine level on the liver metallothionein mRNA level in rats Auteur(s) / Author(s) KOMANG AYU NOCIANITRI (1) ; SAKAKIBARA Shoji (1) ; KANNO Takashi (2) ; KIKUCHI Hiroto (2) ; KURASAKI Masaaki (3) ; AOYAMA Yoritaka (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s) (1) Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Nishi-9, Kita-9, Kita-ku, Sapporo 060-8589, JAPON (2) Nippon Beet Sugar Mfg. Co. Ltd., Nishi-13, Minami-9, Inada-cho, Obihiro 080-0831, JAPON (3) Graduate School of Environmental Earth Science, Hokkaido University, Nishi-6, Kita-10, Kita-ku, Sapporo 060-0810, JAPON
Résumé / Abstract The effects of some methyl-containing compounds added to a choline- deficient diet on the metallothionein mRNA level in the rat liver were studied. The addition of choline or carnitine to the choline- deficient diet did not induce a gain in body weight, while the addition of either betaine or methionine to the choline-deficient diet, or of methionine to the choline-deficient diet with choline significantly increased the body weight. The metallothionein mRNA level in the liver of rats fed on the choline-deficient diet was similar to that of rats fed on the choline-deficient diet with choline, betaine or carnitine. However, the addition of methionine to the choline-deficient diet with or without choline caused a marked suppression in the metallothionein mRNA level in the liver. It is thus surmised that the metallothionein mRNA level in the liver might be regulated by the dietary content of methionine. Revue / Journal Title Bioscience, biotechnology, and biochemistry ISSN 0916-8451 Source / Source 2002, vol. 66, no11, pp. 2465-2470 [6 page(s) (article)] (31 ref.)
>SAMe is effective in preventing formation of primary liver cancer in >rats
Rats have a different metabolism than man.
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>>>SAMe is effective in preventing formation of primary liver cancer in >>>rats
>> Rats have a different metabolism than man.
>How astute. However, we hope you don't dismiss all results from medical >experiments not carried out on live human subjects.
No, surely not. But it is not very intelligent to post all items with the word "iron" in them just to prove something with iron in the metabolism , or the like.
This news-goup - like others - is so much plagued by notorious bullshit posters that normal netizens do not read them. Normal netizens are fed up by the nonsense and hate which floods these news-groups. Many groups and web-forums die because of some few persons who just bombard the net. Look at Jan Drew: more than 60,000 postings in 10 years. But it is not the number of postings, what it important, it is the number of postings filled with nonsense, lies, and hate against any who think scientifically.
One big problem is the religious madness behind these posters. Some agitate against Jews, others attack netizens as "Nazi", want their "exorcism", etc.
The net is a great achievemtn for mankind. One should not throw it away by leaving it to idiots.
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>>>>SAMe is effective in preventing formation of primary liver cancer in >>>>rats
>>> Rats have a different metabolism than man.
>>How astute. However, we hope you don't dismiss all results from medical >>experiments not carried out on live human subjects.
> No, surely not. But it is not very intelligent to post all items with the > word > "iron" in them just to prove something with iron in the metabolism , or > the > like.
If I was trying to make a point that was important to me, I would do just that, and I'm sure you would too. There is validity to IJ's belief that iron is bad for those with liver disease, and disregarding all his posts because they're concerned with iron is doing yourself a disservice if you are interested in liver disease, which I assume you are because of the group/s to which you post.
> This news-goup - like others - is so much plagued by notorious bullshit > posters > that normal netizens do not read them. Normal netizens are fed up by the > nonsense and hate which floods these news-groups. Many groups and > web-forums die > because of some few persons who just bombard the net. Look at Jan Drew: > more > than 60,000 postings in 10 years. But it is not the number of postings, > what it > important, it is the number of postings filled with nonsense, lies, and > hate > against any who think scientifically.
Normal netziens? Hahahahah, now *that's* funny :-) Seriously, the internet is just like any other gathering place, you'll find normal people and wack jobs. You don't have to interact with all of them.
> One big problem is the religious madness behind these posters. Some > agitate > against Jews, others attack netizens as "Nazi", want their "exorcism", > etc. > The net is a great achievemtn for mankind. One should not throw it away by > leaving it to idiots.
The net is indeed a great achievement for mankind. It includes killfile capabilities. Use them.
On Fri, 31 Jul 2009 22:12:45 GMT, "Waterspider" <nos...@all.com> wrote: >There is validity to IJ's belief that iron >is bad for those with liver disease, and disregarding all his posts because >they're concerned with iron is doing yourself a disservice if you are >interested in liver disease, which I assume you are because of the group/s >to which you post.
The point is that he does not understand what he posts with cut+paste. He just "grabs in the bag" and throws the stuff in the net.
>Normal netziens? Hahahahah, now *that's* funny :-)
In contrast to the early days now about 70 percent of the population has net access, if I remember the figure correctly.
>Seriously, the internet is just like any other gathering place, you'll find >normal people and wack jobs. You don't have to interact with all of them.
The important point is that those, who are so bigmouthed and bully the normal netizens, do not represent such a large fraction as their loudness and aggression implies. In other word: a microscopic group dominates millions of people.
The bad thing is, that this microscopic group makes medical claims which, if followed, can lead to the death of your children and of yourself. It is a criminal scene, and it does not matter if they do what they do because they are paid or because the believe in what they do - it is the corpses they leave, what counts.
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